Epzicom

Pronunciation: a-BAK-a-vir/la-MIV-ue-deen
Generic Name: Abacavir/Lamivudine
Brand Name: Epzicom

Severe and sometimes fatal allergic reactions (achiness, cough, diarrhea, difficulty breathing, fever, nausea, rash, sore throat, stomach pain, tiredness, vomiting) have been associated with the use of abacavir. Stop taking Epzicom if any of these symptoms occur and talk with your health care provider. Do not restart Epzicom if symptoms of a severe allergic reaction occur. Severe allergic reactions, including very low blood pressure or death, have occurred in patients who restart Epzicom, even if they have no history or unrecognized symptoms of an allergic reaction. Do not stop and restart Epzicom unless directed to do so by your doctor.

Patients who have a certain gene type called HLA-B*5701 have an increased risk of having an allergic reaction to abacavir. A lab test may be performed before you start Epzicom to see if you have this gene type. Discuss any questions or concerns with your doctor.

High levels of lactic acid in the blood (lactic acidosis) and severe liver problems that can cause death have also been associated with the use of Epzicom. Tell your doctor immediately if you have dark urine, fast or irregular heartbeat, pale stools, rapid or difficult breathing, stomach pain, unusual dizziness or lightheadedness, unusual muscle pain or tenderness, unusual tiredness or weakness, or yellowing of the eyes and skin. Contact your doctor right away if you start to feel unusually cold, especially in your arms and legs, or if you have a general feeling of being unwell. Severe worsening of hepatitis B has been reported in patients who are infected with both HIV and hepatitis B and have discontinued lamivudine. Liver function should be monitored closely for at least several months after discontinuing lamivudine. The long-term effects of Epzicom are not known at this time.

Epzicom is used for:

Treating HIV infection. Epzicom is used in combination with other medicines.

Epzicom is a nucleoside analog reverse transcriptase inhibitor (NRTI) combination. It works by blocking HIV from reproducing.

Do NOT use Epzicom if:

• you are allergic to any ingredient in Epzicom


• you have liver problems, an enlarged liver, abnormal liver function tests, severe kidney problems, or the blood disorder lactic acidosis


• you are taking another medicine that contains abacavir or lamivudine


• you are taking zalcitabine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Epzicom:

Some medical conditions may interact with Epzicom. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney problems, heart problems (eg, a heart attack), high blood pressure, high cholesterol, diabetes, pancreatitis, smoking, alcohol dependence, hepatitis B infection, nerve disorders, or obesity problems


• if you have a history of high levels of lactic acid in the blood or are at risk of liver problems


• if you are taking any other medicine for HIV infection


• if you have been tested and know whether you have a gene type called HLA-B*5701

Some MEDICINES MAY INTERACT with Epzicom. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Interferon alpha or trimethoprim/sulfamethoxazole (TMP-SMZ) because they may increase the risk of Epzicom's side effects


• Ribavirin or zalcitabine because the effectiveness of both medicines may be decreased


• Methadone because its effectiveness may be decreased by Epzicom


• Other medicines that contain abacavir or lamivudine because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Epzicom may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Epzicom:

Use Epzicom as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Epzicom comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Epzicom refilled.


• Take Epzicom by mouth with or without food.


• Taking Epzicom at the same time each day will help you remember to take it.


• Continue to take Epzicom even if you feel well. Do not miss any doses. Failure to do so may decrease the effectiveness of Epzicom and increase the risk that your HIV will no longer be sensitive to Epzicom or to other similar medicines.


• If you miss a dose of Epzicom, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Epzicom.

Important safety information:

• Epzicom may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Epzicom with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Drinking alcohol while taking Epzicom may cause an increased risk of side effects. Talk to your doctor before drinking alcohol while you are taking Epzicom.


• Epzicom is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Epzicom, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.


• If you stop taking Epzicom even for a few days (eg, if you run out of your medicine and do not get it refilled right away), contact your doctor before you start taking it again. You may experience a serious allergic reaction if you stop taking Epzicom and then start again.


• Epzicom does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.


• Epzicom contains abacavir and lamivudine. Before you start any new medicine, check the label to see if it has abacavir or lamivudine in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Carry an ID card at all times that says you take Epzicom.


• Epzicom may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Epzicom.


• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Epzicom. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.


• Diabetes patients - Epzicom may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Patients who have a certain gene type called HLA-B*5701 have an increased risk of a severe or even fatal allergic reaction to Epzicom. A lab test may be performed before you start Epzicom to see if you have this gene type. Discuss any questions or concerns with your doctor.


• Lab tests, including complete blood cell counts and liver function, may be performed while you use Epzicom. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Epzicom should not be used in CHILDREN younger than 18 years; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Epzicom while you are pregnant. Epzicom is found in breast milk. Do not breast-feed while taking Epzicom. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Epzicom to the baby.

Possible side effects of Epzicom:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (fever; rash; tiredness; achiness; nausea; diarrhea; vomiting; stomach pain; sore throat; hives; itching; difficulty breathing; cough; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort, numbness of an arm or leg, shortness of breath, or sudden vision changes; decreased urination; exhaustion; fainting; flu-like illness; mental or mood problems (eg, depression); mouth ulcers; muscle pain, cramping, or weakness; numbness, tingling, or pain in the hands and feet; red, swollen, blistered, or peeling skin; seizures; severe dizziness; swelling; symptoms of lactic acidosis (eg, fast or irregular heartbeat; feeling cold, especially in your arms and legs; rapid or difficult breathing; stomach pain with nausea and vomiting; unusual dizziness or lightheadedness; unusual tiredness or weakness); symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, yellowing of the eyes or skin).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Epzicom side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Epzicom:

Store Epzicom at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Epzicom out of the reach of children and away from pets.

General information:

• If you have any questions about Epzicom, please talk with your doctor, pharmacist, or other health care provider.


• Epzicom is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Epzicom. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Epzicom resources

• Epzicom Side Effects (in more detail)
• Epzicom Use in Pregnancy & Breastfeeding
• Drug Images
• Epzicom Drug Interactions
• Epzicom Support Group
• 1 Review for Epzicom - Add your own review/rating

• Epzicom Prescribing Information (FDA)


• Epzicom Advanced Consumer (Micromedex) - Includes Dosage Information


• Epzicom Consumer Overview

Compare Epzicom with other medications

• HIV Infection
• Nonoccupational Exposure