Comesgen

Comesgen may be available in the countries listed below.

Ingredient matches for Comesgen

Mecobalamin

Mecobalamin is reported as an ingredient of Comesgen in the following countries:

• Japan

International Drug Name Search

Coopercare

Coopercare may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Coopercare

Povidone Iodine

Povidone-Iodine is reported as an ingredient of Coopercare in the following countries:

• United Kingdom

International Drug Name Search

Diclofenbeta

Diclofenbeta may be available in the countries listed below.

Ingredient matches for Diclofenbeta

Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Diclofenbeta in the following countries:

• Germany

International Drug Name Search

Buccoval

Buccoval may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Buccoval

Metronidazole

Metronidazole is reported as an ingredient of Buccoval in the following countries:

• France

Spiramycin

Spiramycin is reported as an ingredient of Buccoval in the following countries:

• France

International Drug Name Search

Ibuprofeno Cuve

Ibuprofeno Cuve may be available in the countries listed below.

Ingredient matches for Ibuprofeno Cuve

Ibuprofen

Ibuprofen is reported as an ingredient of Ibuprofeno Cuve in the following countries:

• Spain

International Drug Name Search

Fermascrub

Fermascrub may be available in the countries listed below.

Ingredient matches for Fermascrub

Chlorhexidine

Chlorhexidine digluconate (a derivative of Chlorhexidine) is reported as an ingredient of Fermascrub in the following countries:

• Japan

International Drug Name Search

Aeropax

Aeropax may be available in the countries listed below.

Ingredient matches for Aeropax

Dimeticone

Dimeticone is reported as an ingredient of Aeropax in the following countries:

• Denmark


• Egypt


• Jordan


• Kuwait


• Lebanon


• Netherlands


• Qatar


• United Arab Emirates


• Yemen

Simeticone

Simeticone is reported as an ingredient of Aeropax in the following countries:

• Netherlands

International Drug Name Search

Cabergolin beta

Cabergolin beta may be available in the countries listed below.

Ingredient matches for Cabergolin beta

Cabergoline

Cabergoline is reported as an ingredient of Cabergolin beta in the following countries:

• Germany

International Drug Name Search

Isosorbide-5-Mononitrato Teva

Isosorbide-5-Mononitrato Teva may be available in the countries listed below.

Ingredient matches for Isosorbide-5-Mononitrato Teva

Isosorbide Mononitrate

Isosorbide Mononitrate is reported as an ingredient of Isosorbide-5-Mononitrato Teva in the following countries:

• Italy

International Drug Name Search

Fusidin-Natrium

Fusidin-Natrium may be available in the countries listed below.

Ingredient matches for Fusidin-Natrium

Fusidic Acid

Fusidic Acid sodium (a derivative of Fusidic Acid) is reported as an ingredient of Fusidin-Natrium in the following countries:

• Russian Federation

International Drug Name Search

Lobelina

Lobelina may be available in the countries listed below.

Ingredient matches for Lobelina

Lobeline

Lobelina (DCIT) is also known as Lobeline (Rec.INN)

International Drug Name Search

Glossary

DCIT	Denominazione Comune Italiana
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Bedoze

Bedoze may be available in the countries listed below.

Ingredient matches for Bedoze

Cyanocobalamin

Cyanocobalamin is reported as an ingredient of Bedoze in the following countries:

• Portugal

International Drug Name Search

Ibuprofeno Acost

Ibuprofeno Acost may be available in the countries listed below.

Ingredient matches for Ibuprofeno Acost

Ibuprofen

Ibuprofen is reported as an ingredient of Ibuprofeno Acost in the following countries:

• Spain

International Drug Name Search

Efesexx

Efesexx may be available in the countries listed below.

Ingredient matches for Efesexx

Sildenafil

Sildenafil is reported as an ingredient of Efesexx in the following countries:

• Peru

International Drug Name Search

Lanciprox

Lanciprox may be available in the countries listed below.

Ingredient matches for Lanciprox

Ciprofloxacin

Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Lanciprox in the following countries:

• Peru

International Drug Name Search

Artrifenac

Artrifenac may be available in the countries listed below.

Ingredient matches for Artrifenac

Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Artrifenac in the following countries:

• El Salvador


• Guatemala

International Drug Name Search

Datolan

Datolan may be available in the countries listed below.

Ingredient matches for Datolan

Eszopiclone

Zopiclone is reported as an ingredient of Datolan in the following countries:

• Spain

International Drug Name Search

Glubitor

Glubitor may be available in the countries listed below.

Ingredient matches for Glubitor

Gliclazide

Gliclazide is reported as an ingredient of Glubitor in the following countries:

• Myanmar


• Philippines

International Drug Name Search

Magnesio Oxide

Magnesio Oxide may be available in the countries listed below.

Ingredient matches for Magnesio Oxide

Magnesium Oxide

Magnesium Oxide is reported as an ingredient of Magnesio Oxide in the following countries:

• Peru

International Drug Name Search

Doxazosina MonteResearch

Doxazosina MonteResearch may be available in the countries listed below.

Ingredient matches for Doxazosina MonteResearch

Doxazosin

Doxazosin is reported as an ingredient of Doxazosina MonteResearch in the following countries:

• Italy

International Drug Name Search

Calcimed

Calcimed may be available in the countries listed below.

Ingredient matches for Calcimed

Calcium Carbonate

Calcium Carbonate is reported as an ingredient of Calcimed in the following countries:

• Turkey

International Drug Name Search

Impugan

Impugan may be available in the countries listed below.

Ingredient matches for Impugan

Furosemide

Furosemide is reported as an ingredient of Impugan in the following countries:

• Bahrain


• Cyprus


• Egypt


• Ethiopia


• Indonesia


• Iraq


• Jordan


• Kuwait


• Lebanon


• Libya


• Qatar


• Saudi Arabia


• Sudan


• Sweden


• United Arab Emirates


• Yemen

International Drug Name Search

Combimax

Combimax may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Combimax

Fenbendazole

Fenbendazole is reported as an ingredient of Combimax in the following countries:

• Australia

Levamisole

Levamisole hydrochloride (a derivative of Levamisole) is reported as an ingredient of Combimax in the following countries:

• Australia

International Drug Name Search

Huminsulin Basal

Huminsulin Basal may be available in the countries listed below.

Ingredient matches for Huminsulin Basal

Insulin, Isophane

Insulin, Isophane human (a derivative of Insulin, Isophane) is reported as an ingredient of Huminsulin Basal in the following countries:

• Austria


• Germany


• Switzerland

International Drug Name Search

Acnu

Acnu may be available in the countries listed below.

Ingredient matches for Acnu

Nimustine

Nimustine hydrochloride (a derivative of Nimustine) is reported as an ingredient of Acnu in the following countries:

• Germany

International Drug Name Search

Lariago

Lariago may be available in the countries listed below.

Ingredient matches for Lariago

Chloroquine

Chloroquine phosphate (a derivative of Chloroquine) is reported as an ingredient of Lariago in the following countries:

• Ethiopia


• India


• Oman

Trimethoprim

Trimethoprim is reported as an ingredient of Lariago in the following countries:

• Ethiopia

International Drug Name Search

Ciprain

Ciprain may be available in the countries listed below.

Ingredient matches for Ciprain

Ciprofloxacin

Ciprofloxacin lactate (a derivative of Ciprofloxacin) is reported as an ingredient of Ciprain in the following countries:

• Mexico

International Drug Name Search

Ciprofloxacin Chephasaar

Ciprofloxacin Chephasaar may be available in the countries listed below.

Ingredient matches for Ciprofloxacin Chephasaar

Ciprofloxacin

Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Ciprofloxacin Chephasaar in the following countries:

• Germany

International Drug Name Search

Finocar

Finocar may be available in the countries listed below.

Ingredient matches for Finocar

Finasteride

Finasteride is reported as an ingredient of Finocar in the following countries:

• Ireland

International Drug Name Search

Bezagamma

Bezagamma may be available in the countries listed below.

Ingredient matches for Bezagamma

Bezafibrate

Bezafibrate is reported as an ingredient of Bezagamma in the following countries:

• Germany

International Drug Name Search

Symlin

Symlin is a brand name of pramlintide, approved by the FDA in the following formulation(s):

SYMLIN (pramlintide acetate - injectable; subcutaneous)

• 
  Manufacturer: AMYLIN
  
  Approval date: March 16, 2005
  
  Strength(s): EQ 3MG BASE/5ML (EQ 600MCG BASE/ML) ^[RLD]


• 
  Manufacturer: AMYLIN
  
  Approval date: September 25, 2007
  
  Strength(s): EQ 1.5MG BASE/1.5ML (EQ 1MG BASE/ML), EQ 2.7MG BASE/2.7ML (EQ 1MG BASE/ML)
  

Has a generic version of Symlin been approved?

No. There is currently no therapeutically equivalent version of Symlin available.

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Symlin. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.

Related Patents

Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.

• 
  Amylin agonist peptides and uses therefor
  Patent 5,686,411
  Issued: November 11, 1997
  Inventor(s): Gaeta; Laura S. L. & Jones; Howard & Albrecht; Elisabeth
  Assignee(s): Amylin Pharmaceuticals, Inc.
  Agonist analogues of amylin and related pharmaceutical compositions, and methods of treatment of diabetes and other insulin-requiring states, as well as methods of treatment of hypoglycemia, are provided.
  
  Patent expiration dates:
  
  
  • March 16, 2019
    
    ✓ 
    Patent use: TREATMENT OF DIABETES WITH AN AMYLIN AGONIST, INCLUDING WITH INSULIN
    ✓ 
    Drug substance
    ✓ 
    Drug product
  
  



• 
  Method and composition for treatment of insulin requiring mammals
  Patent 5,814,600
  Issued: September 29, 1998
  Inventor(s): Rink; Timothy J. & Young; Andrew A.
  Assignee(s): Amylin Pharmaceuticals Inc.
  Method and compositions for treating a mammal by administering to that mammal an insulin (having the in vitro activity of stimulating glucose incorporation into glycogen in rat soleus muscle) and an amylin (having the in vitro activity of suppressing glucose incorporation into glycogen in rat soleus muscle) using specific molar ratios of an insulin to an amylin.
  
  Patent expiration dates:
  
  
  • September 29, 2015
    
    ✓ 
    Patent use: TREATMENT OF A MAMMAL HAVING A NEED OF OR REDUCED ABILITY TO PRODUCE INSULIN WITH AN INSULIN AND AN AMYLIN SUCH AS PRAMLINTIDE
  
  
  
  • September 29, 2015
    
    ✓ 
    Patent use: TREATMENT OF DIABETES WITH AN AMYLIN AGONIST, INCLUDING WITH INSULIN
  
  
  
  • September 29, 2015
    
    ✓ 
    Patent use: TREATMENT OF DIABETES WITH AN AMYLIN AGONIST
  
  



• 
  Methods for regulating gastrointestinal motility
  Patent 6,114,304
  Issued: September 5, 2000
  Inventor(s): Kolterman; Orville G. & Young; Andrew A. & Rink; Timothy J. & Brown; Kathleen Ann Keiting
  Assignee(s): Amylin Pharmaceuticals, Inc.
  Methods for treating conditions associated with elevated, inappropriate or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an amylin agonist alone or in conjunction with other anti-gastric emptying agents. Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are also described.
  
  Patent expiration dates:
  
  
  • September 5, 2017
    
    ✓ 
    Patent use: USE OF AN AMYLIN AGONIST TO REDUCE GASTRIC MOTILITY AND TREAT POST PRANDIAL HYPERGYLCEMIA
  
  
  
  • September 5, 2017
    
    ✓ 
    Patent use: TREATMENT OF DIABETES WITH AN AMYLIN AGONIST
  
  



• 
  Methods for regulating gastrointestinal motility
  Patent 6,608,029
  Issued: August 19, 2003
  Inventor(s): Orville G.; Kolterman & Andrew A.; Young & Timothy J.; Rink & Kathleen Ann; Keating Brown
  Assignee(s): Amylin Pharmaceuticals, Inc.
  Methods for treating conditions associated with elevated, inappropriate or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an amylin agonist alone or in conjunction with other anti-gastric emptying agents. Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are also described.
  
  Patent expiration dates:
  
  
  • September 7, 2013
    
    ✓ 
    Patent use: USE OF AN AMYLIN AGONIST HAVING SPECIFIED BINDING ACTIVITY TO REDUCE GASTRIC MOTILITY, INCLUDING USE THROUGH PARENTERAL ADMINISTRATION
  
  
  
  • September 7, 2013
    
    ✓ 
    Patent use: USE OF AN AMYLIN AGONIST TO REDUCE GASTRIC MOTILITY AND TREAT POST PRANDIAL HYPERGYLCEMIA
  
  
  
  • September 7, 2013
    
    ✓ 
    Patent use: TREATMENT OF DIABETES WITH AN AMYLIN AGONIST
  
  

See also...

• Symlin Consumer Information (Drugs.com)
• Symlin Vial Consumer Information (Wolters Kluwer)
• Symlin Consumer Information (Cerner Multum)
• Symlin Advanced Consumer Information (Micromedex)
• Symlin AHFS DI Monographs (ASHP)
• Pramlintide Consumer Information (Wolters Kluwer)
• Pramlintide Vial Consumer Information (Wolters Kluwer)
• Pramlintide Consumer Information (Cerner Multum)
• Pramlintide Subcutaneous Advanced Consumer Information (Micromedex)
• Pramlintide Acetate AHFS DI Monographs (ASHP)

Ciclosporina Jaba

Ciclosporina Jaba may be available in the countries listed below.

Ingredient matches for Ciclosporina Jaba

Ciclosporin

Ciclosporin is reported as an ingredient of Ciclosporina Jaba in the following countries:

• Portugal

International Drug Name Search

Acido Ursodesossicolico Actavis

Acido Ursodesossicolico Actavis may be available in the countries listed below.

Ingredient matches for Acido Ursodesossicolico Actavis

Ursodeoxycholic Acid

Ursodeoxycholic Acid is reported as an ingredient of Acido Ursodesossicolico Actavis in the following countries:

• Italy

International Drug Name Search

Rosalgin

Rosalgin may be available in the countries listed below.

Ingredient matches for Rosalgin

Benzydamine

Benzydamine hydrochloride (a derivative of Benzydamine) is reported as an ingredient of Rosalgin in the following countries:

• Croatia (Hrvatska)


• Czech Republic


• Portugal


• Spain

International Drug Name Search

Cimzia

In the US, Cimzia (certolizumab systemic) is a member of the drug class TNF alfa inhibitors and is used to treat Crohn's Disease, Crohn's Disease - Acute, Crohn's Disease - Maintenance and Rheumatoid Arthritis.

US matches:

• Cimzia

UK matches:

• Cimzia 200 mg solution for injection (SPC)

Ingredient matches for Cimzia

Certolizumab

Certolizumab Pegol is reported as an ingredient of Cimzia in the following countries:

• Finland


• Germany


• Sweden


• Switzerland


• United Kingdom


• United States

International Drug Name Search

Glossary

SPC	Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Onealfa

Onealfa may be available in the countries listed below.

Ingredient matches for Onealfa

Alfacalcidol

Alfacalcidol is reported as an ingredient of Onealfa in the following countries:

• Japan


• Taiwan

International Drug Name Search

Effect

Effect may be available in the countries listed below.

Ingredient matches for Effect

Paracetamol

Paracetamol is reported as an ingredient of Effect in the following countries:

• Slovakia

International Drug Name Search

Equilibrin

Equilibrin may be available in the countries listed below.

Ingredient matches for Equilibrin

Amitriptylinoxide

Amitriptylinoxide dihydrate (a derivative of Amitriptylinoxide) is reported as an ingredient of Equilibrin in the following countries:

• Germany


• Luxembourg

International Drug Name Search

Seretide Evohaler

Seretide Evohaler may be available in the countries listed below.

Ingredient matches for Seretide Evohaler

Fluticasone

Fluticasone propionate (a derivative of Fluticasone) is reported as an ingredient of Seretide Evohaler in the following countries:

• Bangladesh


• Jamaica


• Oman


• Sweden


• Taiwan


• Trinidad & Tobago

Salmeterol

Salmeterol xinafoate (a derivative of Salmeterol) is reported as an ingredient of Seretide Evohaler in the following countries:

• Jamaica


• Oman


• Sweden


• Taiwan


• Trinidad & Tobago

International Drug Name Search

Inhiplex

Inhiplex may be available in the countries listed below.

Ingredient matches for Inhiplex

Omeprazole

Omeprazole is reported as an ingredient of Inhiplex in the following countries:

• Greece

International Drug Name Search

Alapril

Alapril may be available in the countries listed below.

Ingredient matches for Alapril

Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Alapril in the following countries:

• Austria

Lisinopril

Lisinopril dihydrate (a derivative of Lisinopril) is reported as an ingredient of Alapril in the following countries:

• Italy

International Drug Name Search

Doxazosin Copyfarm

Doxazosin Copyfarm may be available in the countries listed below.

Ingredient matches for Doxazosin Copyfarm

Doxazosin

Doxazosin mesilate (a derivative of Doxazosin) is reported as an ingredient of Doxazosin Copyfarm in the following countries:

• Denmark

International Drug Name Search

Insulin Insulatard HM

Insulin Insulatard HM may be available in the countries listed below.

Ingredient matches for Insulin Insulatard HM

Insulin, Isophane

Insulin, Isophane human (a derivative of Insulin, Isophane) is reported as an ingredient of Insulin Insulatard HM in the following countries:

• Bahrain


• Bangladesh


• Bosnia & Herzegowina


• Georgia


• Guyana


• India


• Ireland


• Israel


• Serbia


• Singapore


• Sri Lanka

International Drug Name Search

Prednison Apotex

Prednison Apotex may be available in the countries listed below.

Ingredient matches for Prednison Apotex

Prednisone

Prednisone is reported as an ingredient of Prednison Apotex in the following countries:

• Netherlands

International Drug Name Search

Elmetin

Elmetin may be available in the countries listed below.

Ingredient matches for Elmetin

Mebendazole

Mebendazole is reported as an ingredient of Elmetin in the following countries:

• Bahrain


• Oman


• Sri Lanka


• Taiwan

International Drug Name Search

Ibuprofen Sandoz

Ibuprofen Sandoz may be available in the countries listed below.

Ingredient matches for Ibuprofen Sandoz

Ibuprofen

Ibuprofen is reported as an ingredient of Ibuprofen Sandoz in the following countries:

• Belgium


• Germany


• Hungary


• Netherlands

International Drug Name Search

Radiogardase

Generic Name: Prussian Blue
Class: Other Ion-removing Agents
VA Class: AD900
Chemical Name: Ferric hexacyanoferrate (II)
Molecular Formula: Fe₄[Fe(CN)₆]₃
CAS Number: 14038-43-8

Introduction

A crystal lattice of ferric hexacyanoferrate (II); an ion-exchange medium with high affinity for cesium and thallium, including radioactive isotopes of these metals.^{1 3}

Uses for Radiogardase

Poisoning and Radioactive Exposure

Treatment of known or suspected internal contamination with radioactive cesium and/or radioactive or nonradioactive thallium following accidental exposure and/or intentional exposure from radioactive terrorism or warfare.^{1 2 3 4 5 6} Reduces the risk of death and major morbidity following exposure to these metals.^{2 4}

Treatment of radioactive exposures when the nature of the radioactive contamination is unknown.^{1 2}

For severe thallium intoxication, may need to employ additional measures (e.g., induction of emesis followed by gastric intubation and lavage, forced diuresis, charcoal hemoperfusion, hemodialysis) to enhance thallium elimination.^{1 7}

Radiogardase Dosage and Administration

General

• 
  

  Initiate therapy as soon as possible after contamination is suspected.¹

  
  


• 
  

  Cesium poisoning: Determine baseline internalized¹³⁷Cs contamination (by whole-body counting, bioassay, or urine/feces sampling) if possible.¹ Measure radioactivity counts in urine and feces weekly to monitor¹³⁷Cs elimination rate.¹ Assess whole-body radioactivity after 30 days of therapy.¹

  
  


• 
  

  Thallium poisoning: Determine baseline internalized thallium contamination (by whole-body counting and/or bioassay) if possible.¹ Monitor CBC and serum chemistry and electrolytes weekly during therapy.¹

  
  

Administration

Oral Administration

Administer orally with food to stimulate excretion of cesium or thallium.¹

If patients cannot tolerate swallowing large numbers of capsules, open the capsules and mix the contents with bland food or liquids.¹

Use with appropriate measures (i.e., oral fiber-based laxatives and/or a high-fiber diet) to promote regular fecal elimination.¹

Can be given with 15% mannitol to prevent constipation.^{3 7 8}

Dosage

Pediatric Patients

Poisoning and Radioactive Exposure

Cesium Poisoning

Oral

Children 2–12 years of age: 1 g 3 times daily.¹

Children ≥13 years of age: 3 g 3 times daily.¹ Once internal radiation has decreased substantially, reduce dosage to 1 or 2 g 3 times daily (to improve GI tolerance).¹

Continue for a minimum of 30 days.¹ Duration of therapy based on level of contamination and clinical judgment.¹

Thallium Poisoning

Oral

Children 2–12 years of age: 1 g 3 times daily.¹

Children ≥13 years of age: 3 g 3 times daily.¹

Duration of therapy based on level of contamination and clinical judgment.¹

Adults

Poisoning and Radioactive Exposure

Cesium Poisoning

Oral

3 g 3 times daily.¹ Once internal radiation has decreased substantially, reduce dosage to 1 or 2 g 3 times daily (to improve GI tolerance).¹

Continue for a minimum of 30 days.¹ Duration of therapy based on level of contamination and clinical judgment.¹

Thallium Poisoning

Oral

3 g 3 times daily.¹

Duration of therapy based on level of contamination and clinical judgment.¹

Special Populations

No special population dosage recommendations at this time.¹

Cautions for Radiogardase

Contraindications

• 
  

  No contraindications according to manufacturer.¹

  
  

Warnings/Precautions

Warnings

Radiation Exposure

Effective only in decreasing radiation exposure; does not treat complications of such exposure.¹ Provide supportive treatment for radiation toxicity (e.g., for severe neutropenia and thrombocytopenia) in conjunction with prussian blue therapy.¹

In radiologic emergencies, the type of elemental exposure may not be known.¹ Prussian blue may not bind to all radioactive elements; therefore, may need to use other radioprotectants (e.g., potassium iodide, edetate calcium disodium, sodium alginate) in addition to prussian blue in patients contaminated with unknown or multiple radioactive elements.^{1 2}

Major Toxicities

GI Effects

Constipation reported frequently; constipation responds to oral administration of fiber (i.e., fiber-based laxatives and/or a high-fiber diet).^{1 3 4}

Decreased GI motility will slow the GI transit time of the prussian blue-metal complex (i.e., prussian blue-¹³⁷Cs, prussian blue-thallium) and may increase exposure to the metal.¹ Caution in individuals with conditions associated with decreased GI motility.¹

General Precautions

Hypokalemia

Hypokalemia (serum potassium concentrations of 2.5–2.9 mEq/L) reported.^{1 3} Closely monitor serum electrolytes.¹

Use with caution in individuals with preexisting cardiac arrhythmias or electrolyte imbalances.¹

Specific Populations

Pregnancy

Category C.¹

Lactation

Prussian blue is unlikely to distribute into breast milk.¹

Cesium and thallium are distributed into human breast milk; women contaminated with these metals should not breast-feed.¹

Pediatric Use

Safety and efficacy and dosage recommendations in pediatric patients ≥2 years of age extrapolated from adult data and supported by experience in pediatric patients (4–12 years of age).¹

Dosing recommendations not established for pediatric patients <2 years of age.¹

Hepatic Impairment

Use not contraindicated; however, may be less effective in these patients due to decreased excretion of cesium and/or thallium in the bile.¹

Renal Impairment

Use not contraindicated.¹

Common Adverse Effects

Constipation,^{1 3 4} GI distress,^{1 4} blue discoloration of sweat and tears (long-term administration).⁷

Interactions for Radiogardase

Orally Administered Drugs and Nutrients

Possible pharmacokinetic interaction (binding of prussian blue to drug and/or essential nutrient).¹ Monitor serum concentrations and/or clinical response in patients receiving clinically important drugs.¹

Specific Drugs

Drug	Interaction	Comments
Radioprotectants	Pharmacologic interaction unlikely; not expected to affect efficacy of prussian blue in the management of137Cs poisoning1
Tetracycline, oral	Possible pharmacokinetic interaction (decreased bioavailability of tetracycline)1	Monitor serum concentrations of and/or clinical response to tetracycline1

Radiogardase Pharmacokinetics

Absorption

Bioavailability

Not appreciably absorbed through intact GI wall.^{1 7}

Elimination

Elimination Route

Eliminated unchanged in feces.¹ Clearance depends on GI transit time.^{1 7}

Stability

Storage

Oral

Capsules

In the dark at 25°C (may be exposed to 15–30°C).¹

ActionsActions

• 
  

  An ion-exchange medium with high affinity for cesium and thallium, including radioactive isotopes of these metals.¹

  
  


• 
  

  Binds cesium and/or thallium in the GI tract, thus preventing absorption or reabsorption of these metals and increasing the rate of their elimination as insoluble complexes in feces.¹

  
  


• 
  

  Reduces whole-body effective half-life of cesium and mean serum biologic half-life of thallium.^{1 4}

  
  


• 
  

  May bind other elements (e.g., potassium).¹ (See Hypokalemia under Cautions.)

  
  

Advice to Patients

• 
  

  Importance of taking prussian blue with food; importance of taking appropriate measures (i.e., oral fiber-based laxatives and/or a high-fiber diet) to promote regular fecal elimination.¹

  
  


• 
  

  Importance of instructing patients on safety measures that should be used to minimize radiation exposure to others, including appropriate disposal of urine and feces.¹ Clothing contaminated with blood or urine should be washed separately.¹

  
  


• 
  

  Advise patients of possible bluish appearance of their stools.¹

  
  


• 
  

  Advise patients who are unable to swallow capsules that their mouth and teeth might be colored blue if prussian blue capsules are opened and the contents mixed with food or liquid.¹

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹

  
  


• 
  

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.¹

  
  


• 
  

  Importance of informing patients of other important precautionary information.¹ (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Prussian Blue (Insoluble)

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Capsules	500 mg	Radiogardase	Heyl Chemisch-pharmazeutische

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions September 2005. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

1. Heyl Chemisch-pharmazeutische. Radiogardase (insoluble Prussian blue) capsules prescribing information. From the FDA web site (). (Accessed 7 Oct 2003).

2. US Food and Drug Administration. Questions and answers on Prussian Blue. From the FDA web site (). (Accessed 2003 Oct 7.)

3. Thompson DF, Church CO. Prussian blue for treatment of radiocesium poisoning. Pharmacotherapy. 2001; 21:1364-7. [IDIS 472544] [PubMed 11714209]

4. US Food and Drug Administration. Guidance for industry on Prussian blue for treatment of internal contamination with thallium or radioactive cesium; availability. [Docket No. 03D-0023.] Fed Regist. 2003; 68:5645-8.

5. US Food and Drug Administration Center for Drug Evaluation and Research. Guidance for industry: Prussian blue drug products—submitting a new drug application. Rockville, MD: FDA; 2003 Jan.

6. American Academy of Pediatrics. Radiation disasters and children: policy statement. Pediatrics. 2003; 111:1455-66. [PubMed 12777572]

7. Hoffman RS. Thallium toxicity and the role of Prussian blue in therapy. Toxicol Rev. 2003; 22:29-40. [IDIS 511730] [PubMed 14579545]

8. Reviewers’ comments (personal observations).

More Radiogardase resources

• Radiogardase Support Group
• 0 Reviews for Radiogardase - Add your own review/rating

• Radiogardase Advanced Consumer (Micromedex) - Includes Dosage Information


• Radiogardase Concise Consumer Information (Cerner Multum)


• Prussian Blue Professional Patient Advice (Wolters Kluwer)

Compare Radiogardase with other medications

• Radiation Emergency

Simvastatin Streuli

Simvastatin Streuli may be available in the countries listed below.

Ingredient matches for Simvastatin Streuli

Simvastatin

Simvastatin is reported as an ingredient of Simvastatin Streuli in the following countries:

• Switzerland

International Drug Name Search

Apo-Domperidone

Apo-Domperidone may be available in the countries listed below.

Ingredient matches for Apo-Domperidone

Domperidone

Domperidone maleate (a derivative of Domperidone) is reported as an ingredient of Apo-Domperidone in the following countries:

• Canada


• Vietnam

International Drug Name Search

Budesonida

Budesonida may be available in the countries listed below.

Ingredient matches for Budesonida

Budesonide

Budesonide is reported as an ingredient of Budesonida in the following countries:

• Chile


• Venezuela

International Drug Name Search

Ceftriaxone Piam

Ceftriaxone Piam may be available in the countries listed below.

Ingredient matches for Ceftriaxone Piam

Ceftriaxone

Ceftriaxone disodium salt (a derivative of Ceftriaxone) is reported as an ingredient of Ceftriaxone Piam in the following countries:

• Italy

International Drug Name Search

Metisone

Metisone may be available in the countries listed below.

Ingredient matches for Metisone

Methylprednisolone

Methylprednisolone is reported as an ingredient of Metisone in the following countries:

• Taiwan

International Drug Name Search

Losartan AbZ

Losartan AbZ may be available in the countries listed below.

Ingredient matches for Losartan AbZ

Losartan

Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Losartan AbZ in the following countries:

• Germany

International Drug Name Search

Ethiodized Oil (131I)

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0008008-53-5

Therapeutic Category

Antineoplastic agent, radioactive isotope

Chemical Name

Fatty acids, poppy seed-oil, Et esters, iodinated, labeled with iodine-131

Foreign Name

• Ethiodat [131I]-Öl (German)

Generic Name

• Ethiodized Oil I 131 (OS: USAN)

Brand Names

• Ethiodol
  Savage, United States



• Lipiodol
  Codali, Belgium; Codali, Luxembourg; Guerbet, Austria; Guerbet, Czech Republic; Guerbet, Germany; Guerbet, France; Guerbet, Georgia; Guerbet, Portugal; Guerbet, Romania; Guerbet, Turkey; Rider, Chile; Temis-Lostalo, Argentina



• Lipiodol Ultra Fluid
  Guerbet Laboratoire, Denmark



• Lipiodol Ultra-fluide
  Guerbet, Switzerland

International Drug Name Search

Glossary

OS	Official Synonym
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Novo-Difenac

Novo-Difenac may be available in the countries listed below.

Ingredient matches for Novo-Difenac

Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Novo-Difenac in the following countries:

• Canada

International Drug Name Search

Trientine Hydrochloride

Trientine Hydrochloride may be available in the countries listed below.

Ingredient matches for Trientine Hydrochloride

Trientine

Trientine Hydrochloride (USAN) is known as Trientine in the US.

International Drug Name Search

Glossary

USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Nularef

Nularef may be available in the countries listed below.

Ingredient matches for Nularef

Loratadine

Loratadine is reported as an ingredient of Nularef in the following countries:

• Argentina

International Drug Name Search

Levamisole Phosphate

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Levamisole Phosphate

Levamisole

Levamisole phosphate (a derivative of Levamisole) is reported as an ingredient of Levamisole Phosphate in the following countries:

• United States

International Drug Name Search

Cinchocaine

In some countries, this medicine may only be approved for veterinary use.

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

C05AD04,D04AB02,N01BB06,S01HA06

CAS registry number (Chemical Abstracts Service)

0000085-79-0

Chemical Formula

C20-H29-N3-O2

Molecular Weight

343

Therapeutic Category

Anesthetic, local

Chemical Names

2-Butoxy-N-[2-(diethylamino)ethyl]cinchoninamide (USAN)

2-Butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide (IUPAC)

4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]- (USAN)

Foreign Names

• Cinchocainum (Latin)
• Cinchocain (German)
• Cinchocaïne (French)
• Cincocaína (Spanish)

Generic Names

• Cinchocaine (OS: BAN)
• Cinchocaïne (OS: DCF)
• Cincocaina (OS: DCIT)
• Dibucaine (OS: USAN)
• 4-22-00-02284 (IS: Beilstein)
• BRN 0275489 (IS)
• UNII-L6JW2TJG99 (IS)
• Dibucaine (PH: USP 32)
• Cinchocaine Hydrochloride (OS: BANM)
• Dibucaine Hydrochloride (OS: JAN, USAN)
• Percaine hydrochloride (IS)
• UNII-Z97702A5DG (IS)
• Cinchocaine (chlorhydrate de) (PH: Ph. Eur. 6)
• Cinchocaine Hydrochloride (PH: BP 2010, Ph. Eur. 6)
• Cinchocainhydrochlorid (PH: Ph. Eur. 6)
• Cinchocaini hydrochloridum (PH: Ph. Eur. 6)
• Dibucaine Hydrochloride (PH: USP 32, JP XV)

Brand Names

• Beselfa (Cinchocaine and Salicylic Acid)
  Towa Yakuhin, Japan



• Cincain Ophtha
  Ophtha, Denmark



• Cincain
  Meda, Sweden



• Dibcalsor (Cinchocaine and Salicylic Acid)
  Nisshin Seiyaku - Yamagata, Japan



• Dikabelin (Cinchocaine and Salicylic Acid)
  Shiono Kemikaru, Japan



• Faktu (Cinchocaine and Policresulen)
  Nycomed, Croatia (Hrvatska)



• Locaseptil-Neo (Cinchocaine and Prednisolone)
  Drossapharm, Switzerland



• Neo Vitacain (Cinchocaine and Salicylic Acid)
  Vitacain Pharmaceutical, Japan



• Nupercainal
  Materfarma, Portugal; Novartis, United States



• Anestesia Local Braun Sin Adrenalina (Cinchocaine and Procaine)
  Braun, Spain



• Decatylen Neo (Cinchocaine and Dequalinium Chloride)
  Mepha Pharma, Switzerland



• Deliproct (Cinchocaine and Prednisolone)
  Clément-Thionville, France



• DoloPosterine
  Kade, Germany



• Faktu (Cinchocaine and Policresulen)
  Altana, Peru; Altana, Slovakia; Nycomed, Germany; Nycomed, Indonesia; Nycomed, Slovenia; Nycomed Pharma, Switzerland; Pharos, Indonesia



• Nabudone (Cinchocaine and Phenylbutazone (veterinary use))
  Ilium Veterinary Products, Australia



• Neopercamin (Cinchocaine and Farmocaine)
  Nagase Iyakuhin, Japan



• Nupercainal
  LPC, Malta; Novartis, United Arab Emirates; Novartis, Bangladesh; Novartis, Bahrain; Novartis, Brazil; Novartis, India; Novartis, Iraq; Novartis, Jordan; Novartis, Kuwait; Novartis, Lebanon; Novartis, Qatar; Novartis, Saudi Arabia; Novartis, Yemen; Novartis Consumer Health, Egypt



• Percamin
  Nagase Iyakuhin, Japan



• Percamin S
  Nagase Iyakuhin, Japan



• Proctosedyl (Cinchocaine and Hydrocortisone)
  Sanofi-Aventis, United Kingdom; Sanofi-Aventis, Norway; Sanofi-Aventis, New Zealand; Sanofi-Aventis, Oman



• Prones (Cinchocaine and Benzocaine)
  Nippon Shika YakuhinDental Pharm, Japan



• Repose (Cinchocaine and Secobarbital (veterinary use))
  Fort Dodge Animale Health, United States



• Scheriproct (Cinchocaine and Prednisolone)
  Bayer, Belgium; Bayer, Switzerland; Bayer, Sweden; Bayer Schering, South Africa; CSL, Australia; Intendis, Austria; Intendis, Luxembourg; Intendis GmbH Berlin, Norway; Meda, United Kingdom



• Supraproct
  Julphar, Oman



• Taiozet (Cinchocaine and Salicylic Acid)
  Taiyo Pharmaceutical, Japan



• Trigain (Cinchocaine and Salicylic Acid)
  Uji Seiyaku, Japan



• Ultraproct (Cinchocaine and Fluocortolone)
  Bayer, Croatia (Hrvatska)



• Uniroid (Cinchocaine and Hydrocortisone)
  Chemidex, United Kingdom

International Drug Name Search

Glossary

BAN	British Approved Name
BANM	British Approved Name (Modified)
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IUPAC	International Union of Pure and Applied Chemistry
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Dimard

Dimard may be available in the countries listed below.

Ingredient matches for Dimard

Hydroxychloroquine

Hydroxychloroquine sulfate (a derivative of Hydroxychloroquine) is reported as an ingredient of Dimard in the following countries:

• Colombia

International Drug Name Search

Ear Clear

Ear Clear may be available in the countries listed below.

Ingredient matches for Ear Clear

Urea

Urea peroxyde (a derivative of Urea) is reported as an ingredient of Ear Clear in the following countries:

• Australia


• New Zealand

International Drug Name Search

Loratadina Ciclum

Loratadina Ciclum may be available in the countries listed below.

Ingredient matches for Loratadina Ciclum

Loratadine

Loratadine is reported as an ingredient of Loratadina Ciclum in the following countries:

• Portugal

International Drug Name Search

Glyade

Glyade may be available in the countries listed below.

Ingredient matches for Glyade

Gliclazide

Gliclazide is reported as an ingredient of Glyade in the following countries:

• Australia


• Taiwan

International Drug Name Search

Ciclidon

Ciclidon may be available in the countries listed below.

Ingredient matches for Ciclidon

Desogestrel

Desogestrel is reported as an ingredient of Ciclidon in the following countries:

• Peru


• Venezuela

Ethinylestradiol

Ethinylestradiol is reported as an ingredient of Ciclidon in the following countries:

• Peru


• Venezuela

International Drug Name Search

Pharma Dynamics Amlodipine Besylate

Pharma Dynamics Amlodipine Besylate may be available in the countries listed below.

Ingredient matches for Pharma Dynamics Amlodipine Besylate

Amlodipine

Amlodipine besilate (a derivative of Amlodipine) is reported as an ingredient of Pharma Dynamics Amlodipine Besylate in the following countries:

• South Africa

International Drug Name Search

Lincmix

Lincmix may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Lincmix

Lincomycin

Lincomycin hydrochloride monohydrate (a derivative of Lincomycin) is reported as an ingredient of Lincmix in the following countries:

• Austria

International Drug Name Search

Natriumvalproat Sandoz

Natriumvalproat Sandoz may be available in the countries listed below.

Ingredient matches for Natriumvalproat Sandoz

Valproic Acid

Valproic Acid sodium (a derivative of Valproic Acid) is reported as an ingredient of Natriumvalproat Sandoz in the following countries:

• Austria

International Drug Name Search

Iprasthma

Iprasthma may be available in the countries listed below.

Ingredient matches for Iprasthma

Ipratropium

Ipratropium Bromide is reported as an ingredient of Iprasthma in the following countries:

• Taiwan

International Drug Name Search

Ipraxa

Ipraxa may be available in the countries listed below.

Ingredient matches for Ipraxa

Ipratropium

Ipratropium Bromide monohydrate (a derivative of Ipratropium Bromide) is reported as an ingredient of Ipraxa in the following countries:

• Netherlands


• Sweden

International Drug Name Search

Difenoxina

Difenoxina may be available in the countries listed below.

Ingredient matches for Difenoxina

Difenoxin

Difenoxina (DCIT) is known as Difenoxin in the US.

International Drug Name Search

Glossary

DCIT	Denominazione Comune Italiana

Click for further information on drug naming conventions and International Nonproprietary Names.

Dentagel

Generic Name: sodium fluoride (Oral route, Dental route, Oromucosal route)

SOE-dee-um FLOOR-ide

Commonly used brand name(s)

In the U.S.

• APF Gel


• Aquafresh


• CaviRinse


• Control Rx


• Denta 5000 Plus


• Dentagel


• Dentall 1100 Plus


• EtheDent


• Fluorabon


• Fluor-A-Day


• Fluoridex Daily Defense


• Fluoridex Daily Defense Enhanced Whitening

In Canada

• Fluorosol


• Koala Pals Fluoride Tooth Gel - Berrylicious Flavor


• Pdf


• Pedi-Dent

Available Dosage Forms:

• Gel/Jelly


• Tablet, Chewable


• Paste


• Solution


• Liquid


• Tablet, Enteric Coated


• Tablet


• Lozenge/Troche


• Cream

Therapeutic Class: Cariostatic

Uses For Dentagel

Fluoride has been found to be helpful in reducing the number of cavities in the teeth. It is usually present naturally in drinking water. However, some areas of the country do not have a high enough level in the water to prevent cavities. To make up for this, extra fluoride may be added to the diet. Some children may require both dietary fluoride and topical fluoride treatments by the dentist. Use of a fluoride toothpaste or rinse may be helpful as well.

Taking extra oral fluoride does not replace good dental habits. These include eating a good diet, brushing and flossing the teeth often, and having regular dental checkups.

Fluoride may also be used for other conditions as determined by your doctor.

This medicine is available only with a prescription.

Importance of Diet

For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.

People get needed fluoride from fish, including the bones, tea, and drinking water that has fluoride added to it. Food that is cooked in water containing fluoride or in Teflon-coated pans also provides fluoride. However, foods cooked in aluminum pans provide less fluoride.

The daily amount of fluoride needed is defined in several different ways.

• For U.S.—


• Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person's age, sex, and physical condition (e.g., pregnancy).


• Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

• For Canada—


• Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

There is no RDA or RNI for fluoride. Daily recommended intakes for fluoride are generally defined as follows:

• Infants and children—


• Birth to 3 years of age: 0.1 to 1.5 milligrams (mg).


• 4 to 6 years of age: 1 to 2.5 mg.


• 7 to 10 years of age: 1.5 to 2.5 mg.

• Adolescents and adults—


• 1.5 to 4 mg.

Remember:

• The total amount of fluoride you get every day includes what you get from the foods and beverages that you eat and what you may take as a supplement.


• This total amount should not be greater than the above recommendations, unless ordered by your health care professional. Taking too much fluoride can cause serious problems to the teeth and bones.

Before Using Dentagel

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts. Doses of sodium fluoride that are too large or are taken for a long time may cause bone problems and teeth discoloration in children.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts. Older people are more likely to have joint pain, kidney problems, or stomach ulcers which may be made worse by taking large doses of sodium fluoride. You should check with your health care professional.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Dairy Food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Brown, white, or black discoloration of teeth or


• Joint pain or


• Kidney problems (severe) or


• Stomach ulcer—Sodium fluoride may make these conditions worse.

Proper Use of sodium fluoride

This section provides information on the proper use of a number of products that contain sodium fluoride. It may not be specific to Dentagel. Please read with care.

Take this medicine only as directed by your health care professional. Do not take more of it and do not take it more often than ordered. Taking too much fluoride over a period of time may cause unwanted effects.

For individuals taking the chewable tablet form of this medicine:

• Tablets should be chewed or crushed before they are swallowed.


• This medicine works best if it is taken at bedtime, after the teeth have been thoroughly brushed. Do not eat or drink for at least 15 minutes after taking sodium fluoride.

For individuals taking the oral liquid form of this medicine:

• This medicine is to be taken by mouth even though it comes in a dropper bottle. The amount to be taken is to be measured with the specially marked dropper.


• Always store this medicine in the original plastic container. Fluoride will affect glass and should not be stored in glass containers.


• This medicine may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food. However, if this medicine is mixed with foods or beverages that contain calcium, the amount of sodium fluoride that is absorbed may be reduced.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (lozenges, solution, tablets, or chewable tablets):
  
  • To prevent cavities in the teeth (not enough fluoride in the water):
    
    • Children—Dose is based on the amount of fluoride in drinking water in your area. Dose is also based on the child's age and must be determined by your health care professional.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Dentagel

The level of fluoride present in the water is different in different parts of the U.S. If you move to another area, check with a health care professional in the new area as soon as possible to see if this medicine is still needed or if the dose needs to be changed. Also, check with your health care professional if you change infant feeding habits (e.g., breast-feeding to infant formula), drinking water (e.g., city water to nonfluoridated bottled water), or filtration (e.g., tap water to filtered tap water).

Do not take calcium supplements or aluminum hydroxide–containing products and sodium fluoride at the same time. It is best to space doses of these two products 2 hours apart, to get the full benefit from each medicine.

Inform your health care professional as soon as possible if you notice white, brown, or black spots on the teeth. These are signs of too much fluoride in children when it is given during periods of tooth development.

Dentagel Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Sodium fluoride in drinking water or taken as a supplement does not usually cause any side effects. However, taking an overdose of fluoride may cause serious problems.

• Sores in the mouth and on the lips (rare)

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

• Black, tarry stools


• bloody vomit


• diarrhea


• drowsiness


• faintness


• increased watering of the mouth


• nausea or vomiting


• shallow breathing


• stomach cramps or pain


• tremors


• unusual excitement


• watery eyes


• weakness

Check with your doctor as soon as possible if any of the following side effects occur:

• Pain and aching of bones


• stiffness


• white, brown, or black discoloration of the teeth—occurs only during periods of tooth development in children

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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Imigrane

Imigrane may be available in the countries listed below.

Ingredient matches for Imigrane

Sumatriptan

Sumatriptan succinate (a derivative of Sumatriptan) is reported as an ingredient of Imigrane in the following countries:

• France

International Drug Name Search

Insulin Actrapid Innolet

Insulin Actrapid Innolet may be available in the countries listed below.

Ingredient matches for Insulin Actrapid Innolet

Insulin Injection, Soluble

Insulin Injection, Soluble human (a derivative of Insulin Injection, Soluble) is reported as an ingredient of Insulin Actrapid Innolet in the following countries:

• Czech Republic

International Drug Name Search

Perikliman

Perikliman may be available in the countries listed below.

Ingredient matches for Perikliman

Estradiol

Estradiol hemihydrate (a derivative of Estradiol) is reported as an ingredient of Perikliman in the following countries:

• Austria

Norethisterone

Norethisterone 17ß-acetate (a derivative of Norethisterone) is reported as an ingredient of Perikliman in the following countries:

• Austria

International Drug Name Search

Iodamide

In the US, Iodamide is a member of the drug class ionic iodinated contrast media.

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

V08AA03

CAS registry number (Chemical Abstracts Service)

0000440-58-4

Chemical Formula

C12-H11-I3-N2-O4

Molecular Weight

627

Therapeutic Category

Contrast medium

Chemical Name

Benzoic acid, 3-(acetylamino)-5-[(acetylamino)methyl]-2,4,6-triiodo-

Foreign Names

• Iodamidum (Latin)
• Iodamid (German)
• Iodamide (French)
• Iodamida (Spanish)

Generic Names

• Iodamide (OS: BAN, JAN, USAN, DCIT, DCF)
• Ametriodinic acid (IS)
• SH 926 (IS)
• Iodamide (PH: JP XIV)
• Meglumine Sodium Iodamide Injection (OS: JAN)
• Meglumine Sodium Iodamide Injection (PH: JP XIV)
• Iodamide Meglumine (OS: USAN)
• Meglumine Iodamide Injection (OS: JAN)
• Iodamide, comp. with N-methylglucamine (IS)
• Radiomiro (IS)
• Rayomiro (IS)
• Triomiro (IS)

Brand Names

• Angiomiron
  Schering, Peru



• Uromiron
  Schering, Colombia; Schering, Peru

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Naphcon A

Naphcon A may be available in the countries listed below.

Ingredient matches for Naphcon A

Naphazoline

Naphazoline hydrochloride (a derivative of Naphazoline) is reported as an ingredient of Naphcon A in the following countries:

• Canada


• New Zealand

Pheniramine

Pheniramine maleate (a derivative of Pheniramine) is reported as an ingredient of Naphcon A in the following countries:

• Canada


• New Zealand

International Drug Name Search